GO0003673 Gene_Ontology GO0003674 molecular_function The action characteristic of a gene product. go curators GO0015643 anti-toxin GO0015644 lipoprotein anti-toxin GO0008435 anticoagulant interpro IPR002389 Annexin type II interpro IPR002392 Annexin type V interpro IPR002390 Annexin type III GO0016172 antifreeze GO0016173 ice nucleation inhibitor GO0016209 antioxidant GO0004362 glutathione reductase (NADPH) ec 1.6.4.2 GO0015933 flavin-containing electron transporter GO0016654 oxidoreductase, acting on NADH or NADPH, disulfide as acceptor ec 1.6.4.- GO0004791 thioredoxin reductase (NADPH) A flavoprotein catalyzing the reaction: NADPH + oxidised thoredoxin = NADP(+) + reduced thioredoxin. isbn 0198547684 ec 1.6.4.5 GO0009388 antisense RNA genprotec 3.1.3.6 antisense RNA GO0016329 apoptosis regulator GO0016506 apoptosis activator A function held by products which directly activate any step in the process of apoptosis. fb hb GO0016505 apoptotic protease activator GO0016504 protease activator GO0008189 apoptosis inhibitor A function held by products which directly block any step in the process of apoptosis. fb hb interpro IPR003429 Apoptosis preventing protein GO0005194 cell adhesion molecule interpro IPR003992 Pertactin interpro IPR003535 Intimin bacterial adhesion mediator protein interpro IPR000421 Coagulation factor 5/8 type C domain (FA58C) interpro IPR002038 Osteopontin interpro IPR001987 Adhesion lipoprotein family interpro IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 interpro IPR002592 Reovirus viral attachment protein sigma 1 interpro IPR003367 Thrombospondin type 3 repeat interpro IPR000782 Beta-Ig-H3/Fasciclin domain interpro IPR001918 Cell attachment sequence interpro IPR000259 Fimbrial proteins interpro IPR002520 Adhesin lipoprotein interpro IPR003328 TILa interpro IPR003536 Translocated intimin receptor (Tir) interpro IPR001389 Flocculin repeat interpro IPR002396 Selectin (CD62E/L/P antigens) interpro IPR000124 Spermadhesin interpro IPR003991 Pertactin virulence factor interpro IPR001082 Fimbrial protein pilin sp_kw Selectin interpro IPR001904 Paxillin family interpro IPR003989 Vascular cell adhesion molecule-1 interpro IPR002567 Cell fusion glycoprotein K interpro IPR000460 Neuroligin interpro IPR003988 Intercellular adhesion molecule GO0008014 calcium-dependent cell adhesion molecule interpro IPR002126 Cadherin domain interpro IPR000233 Cadherin cytoplasmic region GO0001538 cadherin a calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions. isbn 0198506732 GO0016347 calcium-independent cell adhesion molecule GO0004895 cell adhesion receptor interpro IPR001231 CD44 antigen interpro IPR000413 Integrins alpha chain interpro IPR002369 Integrins, beta chain interpro IPR001169 Integrin beta, C-terminus GO0004888 transmembrane receptor interpro IPR000157 TIR domain interpro IPR002184 C.elegans integral membrane protein Srb interpro IPR003110 Immunoreceptor tyrosine-based activation motif interpro IPR001491 Thrombomodulin interpro IPR000609 C.elegans Srg family integral membrane protein interpro IPR003122 Tar ligand binding domain GO0030022 extracellular matrix protein, adhesive GO0005201 extracellular matrix structural protein interpro IPR003506 Chlamydia cysteine-rich outer membrane protein 6 interpro IPR003517 Chlamydia cysteine-rich outer membrane protein 3 sp_kw Connective tissue GO0004384 membrane-associated protein with guanylate kinase activity MAGUK ec 2.7.1.143 GO0004385 guanylate kinase ec 2.7.4.8 interpro IPR000619 Guanylate kinase GO0016773 phosphotransferase, alcohol group as acceptor ec 2.7.1.- GO0005177 neuroligin interpro IPR000460 Neuroligin GO0005102 ligand GO0008337 selectin A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins. isbn 0124325653 interpro IPR002396 Selectin (CD62E/L/P antigens) GO0005530 lectin interpro IPR003990 Pancreatitis-associated protein GO0003750 cell cycle regulator interpro IPR003874 CDC45-like protein interpro IPR003327 Myc leucine zipper sp_kw Mitogen interpro IPR003316 Transcription factor E2F/dimerisation partner (TDP) GO0003751 cyclin sp_kw Cyclin GO0003752 G1/S-specific cyclin GO0003753 G2/M-specific cyclin GO0003754 chaperone GO0003757 GO0003758 GO0003760 GO0003761 Any of a functional class of unrelated families of proteins that assist the correct non-covalent assembly of other polypeptide-containing structures in vivo, but are not components of these assembled structures when they a performing their normal biological function. interpro IPR003708 Bacterial protein export chaperone SecB isbn 0198547684 sp_kw Chaperone genprotec 5.7 chaperoning interpro IPR003435 RbcX protein GO0003763 chaperonin ATPase chaperonin GO0003764 GO0003765 GO0003766 The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.4.9 GO0016821 hydrolase, acting on acid anhydrides, - involved in cellular and subcellular movement ec 3.6.4.- GO0003767 cochaperone GO0003768 GO0003769 GO0003770 GO0003771 GO0003772 cochaperonin GO0015472 fimbrial chaperone GO0003773 heat shock protein Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones. isbn 0198547684 GO0017078 HSC70-interacting GO0005515 protein binding interpro IPR003160 p53-associated protein (MDM2) interpro IPR003101 KIX domain interpro IPR003102 pKID domain GO0008077 HSP70/HSP90 organizing protein GO0003759 lectin-binding chaperone GO0016530 metallochaperone GO0016531 copper chaperone A carrier that delivers copper to specific proteins. pmid 10790544 GO0016532 superoxide dismutase copper chaperone A copper chaperone specifically delivering copper to the Cu-Zn superoxide dismutase (0004785). http //link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html GO0003762 nucleosome assembly chaperone GO0003755 peptidylprolyl isomerase GO0004752 PPIase rotamase sp_kw Rotamase ec 5.2.1.8 GO0016859 cis-trans-isomerase ec 5.2.-.- GO0030053 immunophilin Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block sign al-transduction path-ways leading to T-cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin. isbn 0198506732 GO0004600 cyclophilin A protein to which cyclosporin A (an immunosupressant) binds. Possesses peptidylprolyl isomerase activity. isbn 0198506732 ec 5.2.1.8 GO0030051 FK506-binding isomerase FKBP Any of an extensive family of small proteins to which the immunosuppressant FK506 binds. They are found in many species from bacteria to humans. Like cyclophilin they possess peptidyl-prolyl isomerase activity (EC 5.2.1.8), but have no similarity in structure. Both types belong to the class of proteins termed immunophilins. isbn 0198596732 GO0005528 FK506 binding GO0030052 parvulin A peptidylprolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin. isbn 0198506732 GO0000005 ribosomal chaperone GO0017072 tubulin folding tubulin-specific chaperone GO0008580 cytoskeletal regulator GO0003793 defense/immunity protein interpro IPR003614 Knottin interpro IPR003596 Immunoglobulin V-type sp_kw Defensin interpro IPR003407 Merozoite Antigen interpro IPR003067 Plasmodium circumsporozoite protein interpro IPR003600 Immunoglobulin-like interpro IPR003597 Immunoglobulin C-type interpro IPR002334 Dol/Ves 1 allergen interpro IPR001329 Allergen Api/Dol m 2 interpro IPR003058 Cloacin interpro IPR003298 Apical membrane antigen 1 interpro IPR003598 Immunoglobulin C-2 type interpro IPR003599 Immunoglobulin subtype interpro IPR003354 T-antigen specific domain GO0003794 acute-phase response protein GO0003795 antimicrobial peptide A protein or peptide which inhibits the growth of, or directly kills, microbial cells. go curators GO0003797 antibacterial peptide A protein or peptide which inhibits the growth of, or directly kills, bacterial cells. interpro IPR003254 Insect immunity protein and cecropin go curators interpro IPR003253 Fly sarcotoxin and cecropin GO0008225 gram-negative antibacterial peptide A protein or peptide which inhibits the growth of, or directly kills, gram-negative bacterial cells. go curators GO0008224 gram-positive antibacterial peptide A protein or peptide which inhibits the growth of, or directly kills, gram-positive bacterial cells. go curators GO0003798 male-specific antibacterial peptide A protein or peptide which inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males. go curators GO0003799 antifungal peptide A protein or peptide which inhibits the growth of, or directly kills, fungal cells. go curators GO0008367 bacterial binding GO0008368 gram-negative bacterial binding GO0003796 lysozyme ec 3.2.1.17 interpro IPR000974 Lysozyme interpro IPR002053 Glycosyl hydrolases family 25 interpro IPR002196 Glycoside hydrolase family 24 interpro IPR002152 Lysozyme G GO0004553 hydrolase, hydrolyzing O-glycosyl compounds O-glucosyl hydrolase interpro IPR001919 Cellulose-binding domain, bacterial type interpro IPR001722 Glycoside hydrolase family 7 interpro IPR001764 Glycoside hydrolase family 3, N terminal interpro IPR001547 Glycoside hydrolase family 5 interpro IPR002772 Glycoside hydrolase family 3, C terminal interpro IPR001701 Glycoside hydrolase family 9 interpro IPR002037 Glycoside hydrolase family 8 interpro IPR001724 Glycosyl hydrolase family 58 ec 3.2.1.- interpro IPR001524 Glycoside hydrolase family 6 interpro IPR001649 Glycoside hydrolase family 2 interpro IPR002883 Cellulose-binding domain GO0003800 antiviral response protein GO0003801 blood coagulation factor sp_kw Hemophilia GO0003803 blood coagulation factor IX ec 3.4.21.22 GO0004252 serine-type endopeptidase sp_kw Serine protease interpro IPR000930 Togavirin (S3) serine protease family interpro IPR000710 IgA-specific serine endopeptidase (S6) interpro IPR001984 ATP-dependent serine proteases, Lon family interpro IPR001847 Herpesvirus maturational proteinase, assemblin interpro IPR001815 36KDa capillovirus serine protease (S35) interpro IPR000280 Cattle diarrhoea virus endopeptidase P80 (S31) ec 3.4.21.- interpro IPR000177 Apple domain interpro IPR002142 Peptidase family U7 interpro IPR001940 HtrA/DegQ protease family interpro IPR001316 Alpha-lytic endopeptidase serine protease (S2A) GO0003802 blood coagulation factor VII ec 3.4.21.21 GO0003811 complement component GO0003804 blood coagulation factor X ec 3.4.21.6 GO0003805 blood coagulation factor XI ec 3.4.21.27 GO0003806 blood coagulation factor XII ec 3.4.21.38 GO0003807 plasma kallikrein ec 3.4.21.34 GO0003808 protein C (activated) ec 3.4.21.69 GO0003810 protein-glutamine gamma-glutamyltransferase ec 2.3.2.13 GO0016755 transferase, transferring amino-acyl groups aminoacyltransferase ec 2.3.2.- GO0003809 thrombin ec 3.4.21.5 interpro IPR003966 Prothrombin GO0005209 plasma protein GO0003812 alternative-complement pathway C3/C5 convertase Factor B ec 3.4.21.47 GO0003813 classical-complement pathway C3/C5 convertase ec 3.4.21.43 GO0003815 complement component C1r ec 3.4.21.41 GO0003816 complement component C1s ec 3.4.21.42 GO0003817 complement factor D adipsin ec 3.4.21.46 GO0030009 complement factor H A cofactor for the serine protease complement factor I. isbn 0198547684 GO0003818 complement factor I ec 3.4.21.45 GO0003823 immunoglobulin sp_kw Bence-Jones Protein interpro IPR003006 Immunoglobulin and major histocompatibility complex domain sp_kw Immunoglobulin C region sp_kw Immunoglobulin V region GO0004892 B cell receptor GO0003819 major histocompatibility complex antigen MHC protein sp_kw MHC II sp_kw MHC I sp_kw MHC III interpro IPR000973 T-cell surface glycoprotein CD4 sp_kw MHC GO0003820 class I major histocompatibility complex antigen interpro IPR001039 Major histocompatibility complex protein, Class I GO0008529 endogenous peptide receptor GO0003821 class II major histocompatibility complex antigen interpro IPR000353 Class II histocompatibility antigen, beta chain, beta-1 domain interpro IPR001003 MHC Class II, alpha chain, alpha-1 domain GO0008530 exogenous peptide receptor GO0003822 MHC-interacting protein GO0008229 opsonin GO0003824 enzyme Any naturally occurring or synthetic macromoleular substance composed wholly or largely of protein, that catalyzes, more or less specifically, one or more (bio)chemical reactions at relatively low temperatures. The action of RNA that has catalytic activity (ribozyme) is often also regarded as enzymic. Nevertheless, enzymes are mainly proteinaceous and are often easily inactivated by heating or by protein-denaturing agents. The substances upon which they act are known as substrates, for which the enzyme possesses a specific binding or active site. interpro IPR003607 Metal dependent phosphohydrolase HD domain interpro IPR002912 ACT domain interpro IPR000365 4-hydroxybenzoyl-CoA thioesterase family active site interpro IPR001000 Glycoside hydrolase family 10 interpro IPR000303 ATP-citrate lyase/succinyl-CoA ligases interpro IPR000385 MoaA / nifB / pqqE family interpro IPR000757 Glycoside hydrolase family 16 interpro IPR000624 Cytokinin glycosidase interpro IPR003723 Precorrin-6x reductase CbiJ/CobK interpro IPR000391 Aromatic-ring-hydroxylating dioxygenase, beta subunit interpro IPR000891 HMG-CoA Lyase-like family interpro IPR000312 Glycosyl transferase family interpro IPR001541 SUR2-type hydroxylase/desaturase catalytic domain interpro IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase interpro IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase interpro IPR000669 Mannitol dehydrogenase sp_kw Allosteric enzyme interpro IPR000350 Anthranilate synthase component I and chorismate binding enzyme interpro IPR000457 Glucosamine/galactosamine-6-phosphate isomerase interpro IPR004003 NAD(P) transhydrogenase beta subunit interpro IPR003610 Chitin-binding domain type 3 interpro IPR001087 GDSL lipolytic enzyme interpro IPR000836 Phosphoribosyl transferase interpro IPR000734 Lipase interpro IPR003699 Queuosine biosynthesis protein interpro IPR003692 Hydantoinase B/oxoprolinase interpro IPR000322 Glycoside hydrolase family 31 interpro IPR001150 Pyruvate formate-lyase, glycine radical interpro IPR001544 Aminotransferases class-IV interpro IPR000510 Oxidoreductase, nitrogenase component 1 interpro IPR000805 Glycoside hydrolase family 26 interpro IPR001511 Aminotransferases class-I interpro IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase interpro IPR000627 Intradiol ring-cleavage dioxygenase interpro IPR000901 Carbamoyl-phosphate synthase interpro IPR000310 Orn/Lys/Arg decarboxylases family 1 interpro IPR001045 Spermidine synthase interpro IPR001137 Glycoside hydrolase family 11 interpro IPR000845 Purine and other phosphorylases, family 1 interpro IPR000991 Glutamine amidotransferase class-I interpro IPR001885 Mammalian lipoxygenase interpro IPR001736 Phospholipase D/Transphosphatidylase interpro IPR003779 Carboxymuconolactone decarboxylase interpro IPR000183 Orn/DAP/Arg decarboxylases family 2 interpro IPR001264 Glycosyltransferase family 51 interpro IPR003664 Fatty acid synthesis plsX protein interpro IPR000598 interpro IPR000873 AMP-dependent synthetase and ligase interpro IPR000954 Aminotransferase class-III pyridoxal-phosphate interpro IPR003858 Surface exposed protein, C-terminus interpro IPR000287 Arginase family interpro IPR001603 Tautomerase enzyme interpro IPR000514 Glycoside hydrolase family 39 interpro IPR001017 Dehydrogenase, E1 component interpro IPR003698 Lipoate synthase interpro IPR001509 NAD dependent epimerase/dehydratase family interpro IPR001753 Enoyl-CoA hydratase/isomerase interpro IPR003696 Carbamoyltransferase interpro IPR002698 5-formyltetrahydrofolate cyclo-ligase interpro IPR000581 Dihydroxy-acid and 6-phosphogluconate dehydratase interpro IPR000715 Glycosyl transferase, family 4 interpro IPR000639 Epoxide hydrolase interpro IPR001246 Plant lipoxygenase interpro IPR003702 Acetyl-CoA hydrolase/transferase interpro IPR003704 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit interpro IPR002529 Fumarylacetoacetate (FAA) hydrolase family interpro IPR000794 Beta-ketoacyl synthase interpro IPR000362 Fumarate lyase interpro IPR001345 Phosphoglycerate mutase family interpro IPR003814 Formylmethanofuran dehydrogenase, subunit E interpro IPR000918 Isocitrate lyase interpro IPR000379 Esterase/lipase/thioesterase family active site interpro IPR001093 IMP dehydrogenase / GMP reductase fb ma interpro IPR002044 Glycosyl hydrolase, starch-binding domain interpro IPR000384 Methylglyoxal synthase active site interpro IPR001354 Mandelate racemase/muconate lactonizing enzyme family interpro IPR000486 Extradiol ring-cleavage dioxygenase interpro IPR001143 Bacterial thioester dehydrase interpro IPR004002 Alanine dehydrogenase and pyridine nucleotide transhydrogenase interpro IPR003094 Fructose-2,6-bisphosphatase interpro IPR000490 Glycoside hydrolase family 17 interpro IPR003719 Phenazine biosynthesis PhzC/PhzF protein interpro IPR000868 Isochorismatase hydrolase family interpro IPR000556 Glycoside hydrolase family 48 interpro IPR000887 KDPG and KHG aldolase interpro IPR000907 Lipoxygenase interpro IPR001579 Chitinases family 18 and 2 interpro IPR001330 Prenyltransferase and squalene oxidase repeats interpro IPR003866 Isoflavone reductase interpro IPR001031 Thioesterase interpro IPR000594 UBA/THIF-type NAD/FAD binding fold interpro IPR000728 AIR synthase related protein tigr_role 25500 703 Unknown function Enzymes of unknown specificity interpro IPR003722 Precorrin-8X methylmutase CbiC/CobH interpro IPR001088 Glycoside hydrolase family 4 GO0008661 1-deoxyxylulose-5-phosphate synthase GO0008665 2'-phosphotransferase GO0008485 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidonone 5'-phosphate deaminase GO0008682 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase GO0008685 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO0008686 3,4 dihydroxy-2-butanone-4-phosphate synthase interpro IPR000422 3,4-Dihydroxy-2-butanone 4-phosphate synthase GO0000253 3-keto sterol reductase Enzyme that converts the 3-keto sterol intermediate to the 3-beta-hydroxy; acts in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis. pmid 9811880 GO0008696 4-amino-4-deoxychorismate lyase GO0008699 4-diphosphocytidyl-2C-methyl-D-erythritol synthase interpro IPR001228 4-diphosphocytidyl-2C-methyl-D-erythritol synthase GO0008412 4-hydroxybenzoate octaprenyltransferase GO0008413 7,8-dihydro-8-oxoguanine-triphosphatase interpro IPR003563 7,8-dihydro-8-oxoguanine triphosphatase interpro IPR003561 Mutator MutT interpro IPR003562 Mutator MutX GO0008711 ADP-L-glycero-D-manno-heptose synthase GO0004033 aldo-keto reductase GO0016228 aldolase An enzyme that catalyses an aldol condensation, i.e. a base-catalysed addition reaction of two aldehydes or an aldehyde and a ketone to form an aldol (an organic compound that is both an aldehyde and an alcohol) and its reversal. isbn 0198547684 interpro IPR002915 Deoxyribose-phosphate aldolase GO0008672 2-dehydro-3-deoxyglucarate aldolase ec 4.1.2.20 GO0016832 aldehyde-lyase ec 4.1.2.- GO0008674 2-dehydro-3-deoxyphosphogalactonate aldolase ec 4.1.2.21 GO0008675 2-dehydro-3-deoxyphosphogluconate aldolase ec 4.1.2.14 GO0003849 2-dehydro-3-deoxyphosphoheptonate aldolase interpro IPR001785 DAHP synthetase class I interpro IPR002480 DAHP synthetase classII ec 4.1.2.15 GO0008676 2-dehydro-3-deoxyphosphooctonate aldolase ec 4.1.2.16 GO0008700 4-hydroxy-2-oxoglutarate aldolase ec 4.1.3.16 GO0016833 oxo-acid-lyase ec 4.1.3.- GO0008701 4-hyroxy-2-oxovalerate/4-hydroxy-2-keto-pentanoic acid aldolase ec 4.1.3.- GO0004139 deoxyribose-phosphate aldolase ec 4.1.2.4 GO0004150 dihydroneopterin aldolase interpro IPR003098 Dihydroneopterin aldolase ec 4.1.2.25 GO0004332 fructose-bisphosphate aldolase interpro IPR000771 Fructose-bisphosphate aldolase, class-II interpro IPR000741 Fructose-bisphosphate aldolase, class-I ec 4.1.2.13 GO0008732 L-allo-threonine aldolase ec 4.1.2.- GO0008738 L-fuculose-phosphate aldolase ec 4.1.2.17 GO0008994 rhamnulose-1-phosphate aldolase ec 4.1.2.19 GO0008117 sphinganine-1-phosphate aldolase ec 4.1.2.27 GO0009025 tagatose-bisphosphate aldolase ec 4.1.2.40 GO0004793 threonine aldolase ec 4.1.2.5 GO0004036 alkylbase DNA glycosidase GO0003826 alpha-ketoacid dehydrogenase GO0008402 aromatase cytochrome P450 CYP19 estrogen synthetase GO0015034 cytochrome P450 A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P-450-enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer. medline 92007836 GO0008794 arsenate reductase GO0003833 beta-alanyl-dopamine synthase GO0000251 C-14 sterol reductase sterol C-14 reductase Enzyme that reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. prot P32462 GO0000249 C-22 sterol desaturase Enzyme required to form the C-22(23) double bond in the sterol side chain. prot P54781 GO0000252 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) Enzyme that catalyzes the removal of the 3-alpha hydrogen from the 3-ketocarboxylic acid sterol intermediate, resulting in the decarboxylation of the 3-ketocarboxylic acid: acts in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis. pmid 9811880 GO0000254 C-4 methyl sterol oxidase Enzyme that catalyzes the oxidation of the 4-alpha methyl group of 4,4-dimethylzymosterol, the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis. pmid 9811880 GO0000247 C-8 sterol isomerase delta-8--delta-7 sterol isomerase Enzyme that catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols. prot P32352 GO0009456 carbon-phosphorous lyase GO0008809 carnitine racemase GO0008414 CDP-alcohol phosphotransferase GO0016405 CoA-ligase GO0016207 4-coumarate--CoA ligase 4-coumarate--coenzyme A ligase ec 6.2.1.12 GO0016877 ligase, forming carbon-sulfur bonds ec 6.2.-.- GO0003987 acetate--CoA ligase ec 6.2.1.1 GO0003996 acyl-CoA ligase ec 6.2.1.- GO0008822 crotonobetaine/carnitine-CoA ligase ec 6.3.2.- GO0016881 acid-D-amino acid ligase peptide synthase ec 6.3.2.- GO0008756 O-succinylbenzoate--CoA ligase ec 6.2.1.26 GO0004774 succinate--CoA ligase ec 6.2.1 GO0004775 succinate--CoA ligase (ADP-forming) ec 6.2.1.5 GO0004776 succinate--CoA ligase (GDP-forming) ec 6.2.1.4 GO0008818 cobalamin [5'-phosphate] synthase interpro IPR003805 Cobalamin-5-phosphate synthase CobS GO0008820 cobinamide phosphate guanylyltransferase GO0008719 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase GO0017084 delta-1-pyrroline-5-carboxyate synthetase GO0001512 dihydronicotinamide riboside quinone reductase GO0004153 dihydropterin deaminase GO0004154 dihydropterin oxidase GO0004162 dimethylnitrosamine demethylase GO0008486 diphosphoinositol polyphosphate phosphohydrolase GO0015036 disulfide oxidoreductase interpro IPR001864 Trypanothione reductase interpro IPR001327 FAD-dependent pyridine nucleotide-disulphide oxidoreductase GO0015037 peptide disulfide oxidoreductase GO0015038 glutathione disulfide oxidoreductase GO0009487 glutaredoxin A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase. interpro IPR002109 Glutaredoxin degtyarenko Sep 28 13 08 07 2000 GO0009491 redox-active disulfide bond electron carrier GO0015035 protein disulfide oxidoreductase interpro IPR001853 DSBA oxidoreductase interpro IPR003752 Disulfide bond formation protein DsbB GO0008895 heme lyase/disulfide oxidoreductase GO0003756 protein disulfide isomerase ec 5.3.4.1 GO0000008 thioredoxin A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol. interpro IPR000063 Thioredoxin degtyarenko Sep 28 13 08 07 2000 GO0003686 DNA repair enzyme interpro IPR000093 RecR putative zinc finger interpro IPR003563 7,8-dihydro-8-oxoguanine triphosphatase interpro IPR003561 Mutator MutT interpro IPR003310 G:T/U mismatch-specific DNA glycosylase interpro IPR000035 Alkylbase DNA glycosidase (alkA family) interpro IPR003564 DATP pyrophosphohydrolase interpro IPR003562 Mutator MutX GO0003685 DNA repair protein interpro IPR003027 Rec1 exonuclease interpro IPR002706 XRCC1 N terminal domain interpro IPR001553 RecA bacterial DNA recombination protein interpro IPR002863 DNA mismatch repair protein MutS family, N-terminal domain interpro IPR003011 Rad1 repair protein interpro IPR000686 Fanconi anaemia group C protein interpro IPR001126 UMUC family (DNA-repair) interpro IPR001405 DNA repair protein radC family interpro IPR002625 Smr domain interpro IPR003021 Repair protein Rad1/Rec1 interpro IPR003717 Recombination protein O (RecO) interpro IPR000465 XPA protein interpro IPR002099 DNA mismatch repair proteins mutL/hexB/PMS1 interpro IPR003265 HhH-GPD domain interpro IPR000432 DNA mismatch repair protein MutS family, C-terminal domain interpro IPR001238 RecF protein GO0003904 deoxyribodipyrimidine photolyase interpro IPR000288 DNA photolyase class 2 ec 4.1.99.3 GO0003913 DNA photolyase interpro IPR002081 DNA photolyases class 1 ec 4.1.99.- interpro IPR000474 DNA photolyase GO0003907 formamidopyrimidine-DNA glycosylase interpro IPR000191 Formamidopyrimidine-DNA glycolase interpro IPR000214 Formamidopyrimidine-DNA glycolase, zinc binding domain ec 3.2.2.23 GO0008578 DNA glycolase ec 3.2.2.- GO0008263 G/T-mismatch-specific thymine-DNA glycosylase GO0004844 uracil-DNA glycosylase interpro IPR003250 Poxvirus uracil-DNA glycosylase domain interpro IPR003249 General uracil-DNA glycosylase domain interpro IPR002043 Uracil-DNA glycosylase ec 3.2.2.- GO0017065 single-strand selective monofunctional uracil-DNA glycosylase ec 3.2.2.- GO0004172 ecdysteroid UDP-glucosyl/UDP glucuronosyl transferase GO0008848 enterobactin synthetase nonribosomal peptide synthetase GO0008849 enterochelin esterase GO0008850 enterochelin synthetase interpro IPR003542 Enterobactin synthetase component D GO0008488 gamma-glutamyl carboxylase ec 4.1.1.- GO0008264 glu-tRNA(gln) amidotransferase interpro IPR003837 Glu-tRNAGln amidotransferase C subunit GO0001513 glutamate phosphate reductase GO0004374 glycine cleavage system glycine synthase interpro IPR002930 Glycine cleavage H-protein GO0004133 glycogen debranching enzyme GO0004134 4-alpha-glucanotransferase ec 2.4.1.25 interpro IPR003385 4-alpha-glucanotransferase GO0016758 transferase, transferring hexosyl groups hexosyltransferase interpro IPR002495 Glycosyltransferase family 8 interpro IPR002213 UDP-glucoronosyl and UDP-glucosyl transferase ec 2.4.1.- GO0004135 amylo-1,6-glucosidase ec 3.2.1.33 GO0015926 glucosidase ec 3.2.1.- GO0008891 glycolate oxidase GO0004386 helicase interpro IPR001650 Helicase C-terminal domain interpro IPR003840 Herpes helicase GO0008026 ATP dependent helicase interpro IPR001410 DEAD/DEAH box helicase ec 3.6.1.3 interpro IPR002464 ATP-dependent helicase, DEAH-box interpro IPR000629 ATP-dependent helicase, DEAD-box GO0004002 adenosinetriphosphatase interpro IPR003338 Amino-terminal subdomain, VAT-Nn ec 3.6.1.3 interpro IPR003348 Anion-transporting ATPase GO0004003 ATP dependent DNA helicase interpro IPR001161 Xeroderma pigmentosum group B protein (XP-B) interpro IPR001177 Papillomavirus helicase E1 protein interpro IPR000212 UvrD/REP helicase interpro IPR001945 Xeroderma pigmentosum group D protein ec 3.6.1.3 GO0008094 DNA dependent adenosinetriphosphatase interpro IPR001553 RecA bacterial DNA recombination protein interpro IPR001208 MCM family ec 3.6.1.3 GO0003678 DNA helicase GO0003679 interpro IPR000085 Bacterial DNA recombination protein, RuvA sp_kw Helicase interpro IPR001198 DnaB helicase GO0004004 ATP dependent RNA helicase ec 3.6.1.3 GO0008186 RNA dependent adenosinetriphosphatase ec 3.6.1.3 GO0003724 RNA helicase interpro IPR001850 Flavivirus helicase (NS3) interpro IPR000605 RNA helicase interpro IPR000606 Viral (superfamily 1) RNA helicase GO0017116 single-stranded DNA dependent ATP dependent DNA helicase GO0003677 DNA binding interpro IPR000330 SNF2 related domain interpro IPR001319 Nuclear transition protein 1 interpro IPR003851 Dof zinc finger interpro IPR003025 Otx transcription factor interpro IPR000394 Sigma-54 factor family interpro IPR001162 Excinuclease ABC subunit C domain 2 interpro IPR003221 DNA directed RNA polymerase, 7 kDa subunit interpro IPR000747 'Homeobox' engrailed-type protein interpro IPR002643 Polyomavirus agnoprotein interpro IPR001965 PHD-finger interpro IPR001437 Prokaryotic transcription elongation factor GreA/GreB interpro IPR002059 Cold-shock DNA-binding domain interpro IPR003180 Methylpurine-DNA glycosylase (MPG) interpro IPR003902 GCM motif interpro IPR003077 Peroxisome proliferator-activated receptor, gamma interpro IPR003356 N-6 DNA methylase interpro IPR003069 Ecdysteroid receptor (1H nuclear receptor) interpro IPR000513 5'3'-Exonuclease N- and I-domains interpro IPR003026 Otx1 transcription factor interpro IPR000324 Vitamin D receptor interpro IPR002078 Sigma-54 factor interaction protein family interpro IPR002008 DNA-polymerase family X pol beta-like family interpro IPR001098 Replicative DNA polymerase interpro IPR003022 Otx2 transcription factor interpro IPR003889 FY-rich domain C-terminus interpro IPR001945 Xeroderma pigmentosum group D protein interpro IPR001700 Bacterial RNA polymerase, alpha chain interpro IPR003957 Histone-like transcription factor, archaeal histone and topoisomerase interpro IPR003350 CUT domain interpro IPR000730 Proliferating cell nuclear antigen interpro IPR000344 C.elegans Sra family chemoreceptor interpro IPR001719 AP endonucleases family 2 interpro IPR000862 Replication factor C conserved domain interpro IPR000201 Hepadnaviral P protein N-terminal domain interpro IPR002941 DNA methylase, N-4 and N-6 family interpro IPR000943 Sigma-70 factor family interpro IPR002879 RNA polymerase A/beta'/A interpro IPR000212 UvrD/REP helicase interpro IPR003176 Viral DNA-binding protein interpro IPR001725 RNA polymerases K/14 to 18 Kd subunits interpro IPR001164 Zinc-finger GCS-type interpro IPR001867 Transcriptional regulatory protein, C terminal interpro IPR001982 LAGLIDADG and HNH domains of site-specific DNA intron endonuclease interpro IPR003346 Transposase IS116/IS110/IS902 family interpro IPR001553 RecA bacterial DNA recombination protein interpro IPR003173 Transcriptional Coactivator p15 (PC4) interpro IPR002119 Histone H2A interpro IPR001728 Thyroid hormone receptor interpro IPR000837 Fos transforming protein interpro IPR003656 BED finger interpro IPR001943 UvrB/uvrC motif interpro IPR000678 Nuclear transition protein 2 interpro IPR003034 SAP domain interpro IPR003327 Myc leucine zipper interpro IPR000492 Protamine 2 (PRM2) interpro IPR000565 DNA gyrase, subunit B interpro IPR001022 Tobamoviral movement protein interpro IPR003893 Iroquois-class homeodomain protein motif interpro IPR001386 Histone H1 and H5 family interpro IPR002288 DNA gyrase, subunit B C-terminus interpro IPR003432 Replication terminator protein interpro IPR002926 CONSTANS zinc finger interpro IPR003391 Adenoviral DNA terminal protein interpro IPR000445 Helix-hairpin-helix motif interpro IPR000603 3A movement protein interpro IPR001584 Integrase, catalytic core interpro IPR002863 DNA mismatch repair protein MutS family, N-terminal domain interpro IPR003545 Telomere reverse transcriptase interpro IPR002546 Myogenic Basic domain interpro IPR001306 RNA polymerases L/13 to 16 Kd subunits interpro IPR002865 LexA DNA binding domain interpro IPR001957 Bacterial chromosomal replication initiator protein, DnaA interpro IPR001241 DNA topoisomerase II sp_kw Homeobox interpro IPR001514 RNA polymerases D/30 to 40 Kd subunits interpro IPR001275 DM DNA binding domain interpro IPR000116 High mobility group proteins HMG-I and HMG-Y interpro IPR002694 CHC2 zinc finger interpro IPR001001 DNA polymerase III, beta chain interpro IPR002857 CXXC zinc finger interpro IPR003078 Retinoic acid receptor (1B nuclear receptor) interpro IPR003075 Peroxisome proliferator-activated receptor, beta interpro IPR001723 Steroid hormone receptor interpro IPR000684 Eukaryotic RNA polymerase II heptapeptide repeat interpro IPR003583 Helix-hairpin-helix DNA-binding motif class 1 interpro IPR003141 PHP domain N-terminal region interpro IPR001409 Glucocorticoid receptor interpro IPR003174 Alpha trans-inducing protein (Alpha-TIF) interpro IPR003602 DNA topoisomerase I DNA-binding domain interpro IPR003150 RFX DNA-binding domain interpro IPR001292 Oestrogen receptor interpro IPR001532 Xeroderma pigmentosum group G/yeast RAD superfamily interpro IPR000814 Transcription factor TFIID interpro IPR002296 N6 adenine-specific DNA methyltransferase, N12 class interpro IPR001198 DnaB helicase interpro IPR003888 FY-rich domain N-terminus interpro IPR003415 Telomere-binding protein alpha subunit interpro IPR003956 Histone-like transcription factor (CBF/NF-Y) and archaeal histone, subunit A interpro IPR000119 Bacterial histone-like DNA-binding protein interpro IPR000221 Protamine P1 interpro IPR003222 Antitermination protein interpro IPR001091 N-4 DNA methylase (N4-MTase) interpro IPR003015 Myc-type, helix-loop-helix dimerization domain interpro IPR001606 AT-rich interaction domain (ARID) interpro IPR003074 Peroxisome proliferator-activated receptor (1C nuclear receptor) interpro IPR000055 Restriction modification system, type I interpro IPR003601 DNA topoisomerase I ATP-binding domain interpro IPR001387 Helix-turn-helix motif interpro IPR003073 Orphan nuclear receptor, NURR type interpro IPR003071 Orphan nuclear receptor, HMR type interpro IPR001525 C-5 cytosine-specific DNA methylase interpro IPR000079 Nucleosomal binding domain found in HMG14 and HMG17 interpro IPR000128 Progesterone receptor interpro IPR001739 Methyl-CpG binding domain interpro IPR002104 Phage integrase family interpro IPR002298 DNA-polymerase family A (pol I) interpro IPR001334 Early Protein (E6) interpro IPR001208 MCM family interpro IPR002421 5'-3' Exonuclease interpro IPR001103 Androgen receptor interpro IPR003070 Orphan nuclear receptor (4A nuclear receptor) interpro IPR000380 Prokaryotic DNA topoisomerase I interpro IPR001222 TFIIS zinc ribbon domain interpro IPR003314 Mu DNA-binding domain interpro IPR002205 DNA gyrase/topoisomerase IV, subunit A interpro IPR000040 Acute myeloid leukemia 1 protein (AML 1)/Runt interpro IPR001668 Plasmid recombination enzyme interpro IPR000838 Sigma factor, ECF subfamily interpro IPR001025 BAH (bromo-adjacent homology) domain interpro IPR002341 HSF/ETS DNA-binding domain interpro IPR000969 Structure-specific recognition protein interpro IPR000783 RNA polymerase H/23 kD subunit interpro IPR000411 Topoisomerase IV subunit B interpro IPR001951 Histone H4 interpro IPR001631 Eukaryotic-like DNA topoisomerase I interpro IPR003079 Nuclear receptor ROR family (1F nuclear receptor) interpro IPR002158 Leucine zipper pattern interpro IPR003657 WRKY DNA binding domain interpro IPR002936 Toprim domain interpro IPR000653 DegT/DnrJ/EryC1/StrS family interpro IPR002297 DNA-polymerase gamma, family A interpro IPR001154 Topoisomerase II interpro IPR000910 HMG1/2 (high mobility group) box sp_kw DNA-binding interpro IPR000210 BTB/POZ domain interpro IPR001005 Myb DNA binding domain interpro IPR001161 Xeroderma pigmentosum group B protein (XP-B) interpro IPR000164 Histone H3 interpro IPR000041 Universal stress protein (Usp) interpro IPR002625 Smr domain interpro IPR000135 High mobility group proteins HMG1 and HMG2 interpro IPR003523 COE transcription factor interpro IPR003118 Sterile alpha motif (SAM)/Pointed domain interpro IPR000558 Histone H2B interpro IPR001529 RNA polymerases M/15 Kd subunits interpro IPR003958 Transcription factor (CBF/NF-Y) and archaeal histone interpro IPR003072 Orphan nuclear receptor, NOR1 type interpro IPR000166 Histone-fold/TFIID-TAF/NF-Y domain interpro IPR002054 DNA polymerase family X interpro IPR003106 Homeobox associated leucine zipper interpro IPR000722 RNA polymerase, alpha subunit interpro IPR001572 RNA polymerases beta subunit interpro IPR003076 Peroxisome proliferator-activated receptor, alpha interpro IPR001092 Helix-loop-helix dimerization domain interpro IPR003212 7kD DNA-binding protein interpro IPR001801 H-NS histone family interpro IPR003000 Sir2 family interpro IPR001582 Deoxyribonuclease I interpro IPR003202 DNA polymerase processivity factor (UL42) interpro IPR003340 B3 DNA binding domain interpro IPR003654 OAR domain interpro IPR001510 Poly(ADP-ribose) polymerase zinc finger domain interpro IPR002145 Helix-turn-helix protein, CopG family interpro IPR002064 DNA-directed DNA polymerase family B interpro IPR002815 Type II DNA topoisomerase interpro IPR003115 ParB-like nuclease domain interpro IPR001866 E2 (early) protein, N-terminus interpro IPR002626 Caulimovirus movement protein interpro IPR000637 HMG-I and HMG-Y DNA-binding domain (A+T-hook) interpro IPR003650 Orange domain interpro IPR000003 Retinoic acid receptor interpro IPR003201 Transposase Tn5 interpro IPR001177 Papillomavirus helicase E1 protein interpro IPR003163 Yeast DNA-binding domain interpro IPR003477 PemK-like protein interpro IPR001789 Response regulator receiver domain interpro IPR002092 Bacteriophage-type RNA polymerase family interpro IPR000432 DNA mismatch repair protein MutS family, C-terminal domain interpro IPR002295 N6 adenine-specific DNA methyltransferase, D21 class interpro IPR003216 Linker histone, N-terminus interpro IPR003068 COUP transcription factor (2F nuclear receptor) interpro IPR001616 Alphaherpesvirus alkaline exonuclease interpro IPR002164 Nucleosome assembly protein (NAP) interpro IPR003133 T antigen Ori binding protein interpro IPR002294 N6 adenine-specific DNA methyltransferase, D12 class interpro IPR003227 interpro IPR003584 Helix-hairpin-helix motif class 2 (Pol1-type) interpro IPR002052 N-6 Adenine-specific DNA methylase GO0009378 Holliday junction helicase GO0008722 DNA helicase IV ec 3.6.1.- GO0016818 hydrolase, acting on acid anhydrides, in phosphorus-containing anhydrides ec 3.6.1.- GO0003723 RNA binding interpro IPR002646 Poly A polymerase family interpro IPR001788 RNA dependent RNA polymerase interpro IPR002693 Paramyxovirus P phosphoprotein interpro IPR000999 Ribonuclease III family interpro IPR001352 Ribonuclease HII interpro IPR003029 S1 RNA binding domain interpro IPR002873 Rotavirus non-structural protein NSP3 interpro IPR000607 Double-stranded RNA-specific adenosine deaminase (DRADA) repeat interpro IPR003224 P-11 zinc finger interpro IPR001797 2'-5'-oligoadenylate synthetase interpro IPR000692 Fibrillarin interpro IPR000061 SWAP / SURP interpro IPR000110 Ribosomal protein S1 interpro IPR003604 U1-like zinc finger interpro IPR000824 Tryptophan RNA-binding attenuator protein interpro IPR002344 Lupus La protein interpro IPR001787 Ribosomal protein L21 sp_kw RNA-binding interpro IPR002588 Viral methyltransferase interpro IPR003890 Middle domain of eIF4G interpro IPR001081 Ribosomal protein L20 interpro IPR001410 DEAD/DEAH box helicase interpro IPR001313 Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain) interpro IPR000477 RNA-directed DNA polymerase (Reverse transcriptase) interpro IPR003210 Signal recognition particle 14kD protein interpro IPR000606 Viral (superfamily 1) RNA helicase interpro IPR001887 Barnase interpro IPR002466 Adenosine-deaminase (editase) domain interpro IPR002649 tRNA (guanine-N1-)-methyltransferase interpro IPR000123 RNA-directed DNA polymerase (Reverse transcriptase), msDNA interpro IPR001566 RNA methyltransferase trmA family interpro IPR003751 Carbon storage regulator interpro IPR000256 Influenza non-structural protein (NS1) interpro IPR002942 S4 domain sp_kw rRNA-binding interpro IPR001900 Ribonuclease II domain interpro IPR002905 N2,N2-dimethylguanosine tRNA methyltransferase interpro IPR001591 Orthomyxoviridae RNA polymerase subunit PB2 interpro IPR001016 Viral RNA-dependent RNA polymerase, L protein interpro IPR001892 Ribosomal protein S13 interpro IPR002506 Hepatitis delta virus delta antigen interpro IPR002564 Viral RNA dependent RNA polymerase interpro IPR001040 Eukaryotic translation initiation factor 4E (eIF-4E) interpro IPR000139 Antitermination protein NusB sp_kw tRNA-binding interpro IPR002778 SRP19 protein interpro IPR001850 Flavivirus helicase (NS3) interpro IPR003668 Rotavirus non-structural protein (ns35) interpro IPR003286 C.elegans hypothetical protein (pol-like reverse transciptase) interpro IPR000037 SmpB protein interpro IPR002581 Morbillivirus RNA polymerase alpha subunit interpro IPR001247 3' exoribonuclease family interpro IPR001014 Ribosomal L23 protein interpro IPR002343 Paraneoplastic encephalomyelitis antigen interpro IPR002148 Rotavirus RNA-binding Protein 53 (NS53) interpro IPR001795 Luteovirus (ORF3) RNA-directed RNA-polymerase interpro IPR001568 Ribonuclease T2 family interpro IPR002166 Hepatitis C virus RNA dependent RNA polymerase interpro IPR002478 PUA domain interpro IPR000026 Guanine-specific ribonuclease N1 and T1 interpro IPR001550 Transcriptional antiterminators bglG family interpro IPR000605 RNA helicase interpro IPR001009 Influenza RNA polymerase, P2 subunit interpro IPR002583 Ribosomal protein S20 interpro IPR001537 tRNA/rRNA methyltransferase (SpoU) interpro IPR002702 Bacteriophage translational regulator GO0015002 heme-copper terminal oxidase A multisubunit transmembrane protein catalyzing the four-electron reduction of dioxygen to water, coupled to generation of a proton electrochemical gradient across the membranes in which it is embedded. degtyarenko Sep 28 13 08 07 2000 GO0009481 aa3-type cytochrome-c oxidase ec 1.9.3.1 GO0015198 oligopeptide transporter GO0015422 oligosaccharide-transporting ATPase The import of lactose, melibiose and raffinose by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.3.18 GO0015423 maltose-transporting ATPase The import of maltose and maltose oligosaccharides by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.3.19 GO0005363 maltose transporter GO0015415 phosphate porter The import of phosphate anions by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases tc 3.A.1.7.1 ec 3.6.3.27 GO0015114 phosphate transporter GO0015416 phosphonate/organo-phosphate ester porter (broad specificity) The import of phosphonate and organophosphate anions by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. tc 3.A.1.9.1 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.3.28 GO0015605 organo-phosphate ester transporter GO0015417 polyamine porter The import of putrescine and spermidine by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. ec 3.6.3.31 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases tc 3.A.1.11.1 GO0015203 polyamine transporter GO0015594 putrescine porter ec 3.6.3.31 tc 3.A.1.11.2 GO0015489 putrescine transporter GO0015595 spermidine porter ec 3.6.3.31 tc 3.A.1.11.- GO0015606 spermidine transporter GO0015418 quaternary amine uptake transporter The import of betaine and glycine by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. ec 3.6.3.32 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases tc 3.A.1.12.- GO0015596 glycine betaine/proline porter tc 3.A.1.12.1 ec 3.6.3.32 GO0015199 betaine transporter GO0015187 glycine transporter GO0015193 proline transporter GO0015419 sulfate/thiosulfate porter The import of sulfate and thiosulfate anions by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. tc 3.A.1.6.1 ec 3.6.3.25 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases GO0015116 sulfate transporter GO0015117 thiosulfate transporter GO0015411 taurine (2-aminoethane sulfonate) porter The import of taurine by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.3.36 tc 3.A.1.17.1 GO0005368 taurine transporter GO0015420 vitamin B12 porter The import of cobalamin derivatives by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. ec 3.6.3.33 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases tc 3.A.1.13.1 GO0015235 vitamin B12 transporter GO0003936 hydrogen-transporting two-sector ATPase interpro IPR002699 ATP synthase subunit D interpro IPR000711 ATP synthase, delta (OSCP) subunit interpro IPR003237 Avian mitochondrial ATPase subunit 8 interpro IPR000131 ATP synthase gamma subunit interpro IPR001421 Mitochondrial ATPase subunit 8 interpro IPR000194 ATP synthase alpha and beta subunit, N-terminal interpro IPR003255 ATP synthase beta subunit, C-terminal interpro IPR002146 ATP synthase B/B' CF(0) interpro IPR000454 Eubacterial and plasma membrane ATP synthase subunit C interpro IPR003238 Mammalian mitochondrial ATPase subunit 8 interpro IPR002490 V-type ATPase 116kDa subunit family ec 3.6.3.14 interpro IPR001469 ATP synthase, Delta/Epsilon chain tc 3.A.2.1.- interpro IPR000790 ATP synthase alpha subunit, C-terminal interpro IPR000793 ATP synthase alpha and beta subunit, C-terminal interpro IPR002843 ATP synthase (C/AC39) subunit interpro IPR000568 ATP synthase A subunit interpro IPR000245 Vacuolar ATP synthase 16kD subunit interpro IPR002379 ATP synthase subunit C GO0015442 hydrogen-/sodium-translocating ATPase genprotec 4.3.A.2 The H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily tc 3.A.2.-.- GO0016466 hydrogen-translocating A-type ATPase tc 3.A.2.3.1 GO0015078 hydrogen transporter proton transporter GO0016467 hydrogen-translocating F-type ATPase ATP synthase F1-ATPase tc 3.A.2.1.3 tc 3.A.2.1.1 GO0000260 hydrogen-translocating V-type ATPase tc 3.A.2.2.1 interpro IPR002841 ATP synthase (F/14-kDa) subunit tc 3.A.2.2.3 interpro IPR002842 ATP synthase (E/31 kDa) subunit GO0008900 hydrogen/potassium-exchanging ATPase GO0005390 proton pump A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. Catalyses the efflux of one hydrogen ion and the influx of one potassium ion per ATP hydrolysed. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.3.10 GO0004012 magnesium-ATPase A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme apparently has several activities, one of them being the movement of phospholipids from one membrane face to the other ('flippase'). ec 3.6.3.1 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases GO0004005 plasma membrane cation-transporting ATPase interpro IPR001757 E1-E2 ATPases interpro IPR000695 H+-transporting ATPase (proton pump) interpro IPR000579 Cation-transporting P-type ATPase A GO0005386 carrier carrier type transporter interpro IPR001703 Alpha-fetoprotein interpro IPR000264 Serum albumin family interpro IPR000213 Vitamin D-binding protein GO0008567 dynein ATPase dynein The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.4.2 GO0008568 microtubule-severing ATPase katanin The splitting of microtubules into tubulin dimers in the centrosome by an AAA-ATPase. ec 3.6.4.3 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases GO0008569 minus-end-directed kinesin ATPase The hydrolysis of ATP (and GTP) that drives the microtubular motor towards the minus-end of microtubules. ec 3.6.4.5 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases GO0016326 kinesin motor The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules. fb hb GO0008570 myosin ATPase actomyosin The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.4.1 GO0008571 non-chaperonin molecular chaperone ATPase Hsc70 . fb ma ec 3.6.4.10 GO0008572 nucleoplasmin ATPase The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes. ec 3.6.4.11 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases GO0008573 peroxisome-assembly ATPase peroxisome assembly factor-2 ATP hydrolysis to import and assemble peroxisome components into the organelle. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.4.7 GO0008574 plus-end-directed kinesin ATPase kinesin The hydrolysis of ATP (and GTP) that drives the microtubular motor towards the plus-end of microtubules. ec 3.6.4.4 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases GO0008575 proteasome ATPase The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.4.8 GO0008576 vesicle-fusing ATPase The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.4.6 GO0003998 acylphosphatase interpro IPR001792 Acylphosphatase ec 3.6.1.7 GO0008796 bis(5'-nucleosyl)-tetraphosphatase ec 3.6.1.- interpro IPR003565 Bis(5'-nucleosyl)-tetraphosphatase GO0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) ec 3.6.1.17 GO0008803 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ec 3.6.1.41 GO0008828 dATP pyrophosphohydrolase ec 3.6.1.- interpro IPR003564 DATP pyrophosphohydrolase GO0004309 exopolyphosphatase ec 3.6.1.11 GO0003924 GTPase Any enzymic activity that hydrolyzes GTP to GDP and orthophosphate. ec 3.6.1.- isbn 0198547684 interpro IPR003191 Guanylate-binding protein interpro IPR003575 Small GTPase, Ras subfamily interpro IPR003130 Dynamin GTPase effector domain GO0005525 GTP binding interpro IPR002976 Plant G-protein, alpha subunit interpro IPR000795 GTP-binding elongation factor interpro IPR001114 Adenylosuccinate synthetase interpro IPR003579 RAS small GTPases, Rab subfamily interpro IPR000367 G-protein alpha subunit group S interpro IPR000654 G-protein alpha subunit, group Q interpro IPR003578 RAS small GTPases, Rho subfamily sp_kw GTP-binding interpro IPR003191 Guanylate-binding protein interpro IPR000251 ADP-ribosylation factors family interpro IPR000640 Elongation factor G, C-terminus interpro IPR003575 Small GTPase, Ras subfamily interpro IPR000178 Initiation factor 2 interpro IPR002041 GTP-binding nuclear protein Ran family interpro IPR000375 Dynamin central region interpro IPR000469 G-protein alpha subunit group 12 interpro IPR000649 Initiation factor 2B interpro IPR001401 Dynamin family interpro IPR002046 SAR1 GTP-binding protein family interpro IPR003285 Yeast eukaryotic release factor interpro IPR003130 Dynamin GTPase effector domain interpro IPR001806 Ras GTPase superfamily interpro IPR001408 G-protein alpha subunit group I interpro IPR000364 Phosphoenolpyruvate carboxykinase (GTP) interpro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit interpro IPR003577 RAS small GTPases, Ras subfamily interpro IPR002975 Fungal G-protein, alpha subunit GO0008549 dynamin GTPase An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.1.50 GO0003927 heterotrimeric G-protein GTPase GTP-hydrolysing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and imhibitory G-proteins such as Gs, Gi, Go and Golf, targetting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.1.46 GO0000263 heterotrimeric G-protein GTPase, alpha subunit Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity. sgd mah ec 3.6.1.46 GO0000264 heterotrimeric G-protein GTPase, beta subunit Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit. sgd mah ec 3.6.1.46 GO0000265 heterotrimeric G-protein GTPase, gamma subunit Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit. sgd mah ec 3.6.1.46 GO0008547 protein-synthesizing GTPase A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyses it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolysing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyse binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyse the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs. ec 3.6.1.48 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases GO0008135 translation factor egad translation factors tigr_role 21050 169 Protein synthesis Translation factors GO0016147 protein-synthesizing GTPase, elongation ec 3.6.1.48 GO0003746 translation elongation factor GO0008182 GO0008183 any member of a group of soluble proteins required for chain elongation during polypeptide synthesis at the ribosome. isbn 0198506732 interpro IPR003037 TS-N domain sp_kw Elongation factor interpro IPR000795 GTP-binding elongation factor interpro IPR001662 Elongation factor 1 gamma chain interpro IPR000640 Elongation factor G, C-terminus interpro IPR001816 Elongation factor Ts interpro IPR001326 Elongation factor 1 beta/beta'/delta chain interpro IPR001059 Elongation factor P (EF-P) GO0016146 protein-synthesizing GTPase, initiation ec 3.6.1.48 GO0003743 translation initiation factor GO0003744 GO0003745 any of a group of soluble proteins functioning in the initiation of ribosome-mediated translation of mRNA into a polypeptide. isbn 0198506732 interpro IPR000649 Initiation factor 2B interpro IPR001288 Initiation factor 3 interpro IPR001884 Eukaryotic initiation factor 5A hypusine (eIF-5A) interpro IPR001253 Eukaryotic initiation factor 1A interpro IPR002769 eIF-6 family interpro IPR001950 Translation initiation factor SUI1 interpro IPR001040 Eukaryotic translation initiation factor 4E (eIF-4E) interpro IPR003307 eIF4-gamma/eIF5/eIF2-epsilon sp_kw initiation factor interpro IPR002735 Domain found in IF2B/IF5 interpro IPR000178 Initiation factor 2 GO0016148 protein-synthesizing GTPase, termination ec 3.6.1.48 GO0008079 translation termination factor A protein that participates in the termination of translation. fb ma GO0008548 signal-recognition-particle GTPase GTPase activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis). ec 3.6.1.49 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases GO0003925 small monomeric GTPase Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies). ec 3.6.1.47 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases interpro IPR002041 GTP-binding nuclear protein Ran family interpro IPR001806 Ras GTPase superfamily GO0003926 ARF small monomeric GTPase ec 3.6.1.47 GO0003928 RAB small monomeric GTPase ec 3.6.1.47 interpro IPR003579 RAS small GTPases, Rab subfamily GO0003929 RAN small monomeric GTPase ec 3.6.1.47 GO0003930 RAS small monomeric GTPase ec 3.6.1.47 interpro IPR003577 RAS small GTPases, Ras subfamily GO0008619 RHEB small monomeric GTPase ec 3.6.1.47 GO0003931 RHO small monomeric GTPase Any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. interpro IPR003578 RAS small GTPases, Rho subfamily ec 3.6.1.47 sgd mah GO0003932 SAR small monomeric GTPase ec 3.6.1.47 GO0008550 tubulin GTPase An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others. iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases ec 3.6.1.51 GO0004427 inorganic diphosphatase ec 3.6.1.1 GO0017110 nucleoside diphosphatase ec 3.6.1.6 GO0004050 apyrase An enzyme that hydrolyses ATP to AMP and inorganic phosphate. Requires either calcium or magnesium as activating ions. Also acts on ADP, and on other nucleoside triphosphates and diphosphates. ec 3.6.1.5 iubmb Proposed Changes to the Enzyme List concerning ATPases and GTPases GO0004382 guanosine-diphosphatase ec 3.6.1.42 GO0017111 nucleoside triphosphatase ec 3.6.1.15 GO0016462 pyrophosphatase ec 3.6.1.- interpro IPR001596 Inorganic pyrophosphatase GO0016302 phosphatase interpro IPR001952 Alkaline phosphatase family interpro IPR003695 Ppx/GppA phosphatase GO0008715 CDP-diacylglycerol pyrophosphatase interpro IPR003763 CDP-diacylglycerol pyrophosphatase ec 3.6.1.26 GO0004170 dUTP pyrophosphatase ec 3.6.1.23 GO0008894 guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase ec 3.6.1.40 GO0009678 hydrogen-translocating pyrophosphatase Transporter that pumps hydrogen, generating a proton motive force upon hydrolysis of pyrophosphate. tc 3.A.10.-.- http //www-biology.ucsd.edu/~msaier/transport/3_A_10.html GO0000210 NAD+ pyrophosphatase Enzyme that catalyzes the hydrolysis of NAD⁺ to yield AMP plud NMN. ec 3.6.1.22 GO0004551 nucleotide pyrophosphatase ec 3.6.1.9 GO0004636 phosphoribosyl-ATP pyrophosphatase ec 3.6.1.31 interpro IPR002497 Phosphoribosyl-ATP pyrophosphohydrolase GO0004787 thiamine pyrophosphatase ec 3.6.1.- GO0008768 UDP-sugar diphosphatase ec 3.6.1.45 GO0016819 hydrolase, acting on acid anhydrides, in sulfonyl-containing anhydrides ec 3.6.2.- GO0016822 hydrolase, acting on acid carbon-carbon bonds ec 3.7.-.- GO0016823 hydrolase, acting on acid carbon-carbon bonds, in ketonic substances ec 3.7.1.- GO0008680 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase ec 3.7.1.- GO0004334 fumarylacetoacetase ec 3.7.1.2 GO0016827 hydrolase, acting on acid carbon-phosphorus bonds ec 3.11.-.- GO0016824 hydrolase, acting on acid halide bonds ec 3.8.-.- GO0004800 thyroxine deiodinase ec 3.8.1.4 interpro IPR000643 Iodothyronine deiodinase GO0016825 hydrolase, acting on acid phosphorus-nitrogen bonds ec 3.9.-.- GO0016826 hydrolase, acting on acid sulfur-nitrogen bonds ec 3.10.-.- GO0016250 N-sulfoglucosamine sulfohydrolase ec 3.10.1.1 GO0016828 hydrolase, acting on acid sulfur-sulfur bonds ec 3.12.-.- GO0016810 hydrolase, acting on carbon-nitrogen (but not peptide) bonds interpro IPR002509 Polysaccharide deacetylase interpro IPR003010 Carbon-nitrogen hydrolase ec 3.5.-.- GO0016812 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides ec 3.5.2.- GO0004038 allantoinase ec 3.5.2.5 GO0008800 beta-lactamase ec 3.5.2.6 GO0004151 dihydroorotase ec 3.5.2.3 GO0004157 dihydropyrimidinase ec 3.5.2.2 GO0016814 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines ec 3.5.4.- interpro IPR001365 Adenosine and AMP deaminase GO0000034 adenine deaminase ec 3.5.4.2 interpro IPR002832 Adenine deaminase GO0004000 adenosine deaminase ec 3.5.4.4 interpro IPR002466 Adenosine-deaminase (editase) domain GO0003726 double-stranded RNA adenosine deaminase interpro IPR000607 Double-stranded RNA-specific adenosine deaminase (DRADA) repeat GO0003725 double-stranded RNA binding interpro IPR001159 Double-stranded RNA binding (DsRBD) domain GO0003969 RNA editase GO0008251 tRNA specific adenosine deaminase GO0003876 AMP deaminase ec 3.5.4.6 GO0004126 cytidine deaminase ec 3.5.4.5 GO0004131 cytosine deaminase ec 3.5.4.1 GO0004132 dCMP deaminase ec 3.5.4.12 GO0008829 dCTP deaminase ec 3.5.4.13 GO0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase ec 3.5.4.26 GO0003933 GTP cyclohydrolase ec 3.5.4.- GO0003934 GTP cyclohydrolase I interpro IPR001474 GTP cyclohydrolase I ec 3.5.4.16 GO0003935 GTP cyclohydrolase II ec 3.5.4.25 interpro IPR000926 GTP cyclohydrolase II GO0008892 guanine deaminase ec 3.5.4.3 GO0003937 IMP cyclohydrolase inosinicase interpro IPR002695 AICARFT/IMPCHase bienzyme ec 3.5.4.10 GO0004477 methenyltetrahydrofolate cyclohydrolase ec 3.5.4.9 GO0004635 phosphoribosyl-AMP cyclohydrolase interpro IPR002496 Phosphoribosyl-AMP cyclohydrolase ec 3.5.4.19 GO0016811 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ec 3.5.1.- GO0008777 acetylornithine deacetylase ec 3.5.1.16 GO0004039 allophanate hydrolase ec 3.5.1.54 GO0004040 amidase acetamidase interpro IPR000120 Amidase interpro IPR002901 N-acetylmuramoyl-L-alanine amidase (family 4) ec 3.5.1.4 interpro IPR002586 Cobyrinic acid a,c-diamide synthase GO0004046 aminoacylase ec 3.5.1.14 GO0004061 arylformamidase ec 3.5.1.9 GO0004067 asparaginase interpro IPR000246 Asparaginase 2 family ec 3.5.1.1 GO0003948 N4-(beta-N-acetylglucosaminyl)-L-asparaginase ec 3.5.1.26 GO0008418 protein N-terminal asparagine amidohydrolase ec 3.5.1.- GO0003837 beta-ureidopropionase ec 3.5.1.6 GO0017040 ceramidase ec 3.5.1.23 GO0004336 galactosylceramidase interpro IPR001286 Glycoside hydrolase family 59 ec 3.2.1.46 GO0017041 galactosylgalactosylglucosylceramidase ec 3.2.1.47 GO0004348 glucosylceramidase ec 3.2.1.45 interpro IPR001139 Glycoside hydrolase family 30 GO0017042 glycosylceramidase ec 3.2.1.62 GO0004099 chitin deacetylase ec 3.5.1.41 GO0017064 fatty acid amide hydrolase GO0004328 formamidase ec 3.5.1.49 GO0008463 formylmethionine deformylase ec 3.5.1.31 interpro IPR000181 Formylmethionine deformylase GO0008864 formyltetrahydrofolate deformylase ec 3.5.1.10 GO0004359 glutaminase ec 3.5.1.2 GO0008884 glutathionylspermidine amidase ec 3.5.1.78 GO0008421 long-chain-fatty-acyl-glutamate deacylase ec 3.5.1.55 GO0008448 N-acetylglucosamine-6-phosphate deacetylase interpro IPR003764 N-acetylglucosamine-6-phosphate deacetylase ec 3.5.1.25 GO0008745 N-acetylmuramoyl-L-alanine amidase interpro IPR002502 N-acetylmuramoyl-L-alanine amidase (family 2) interpro IPR002508 Cell wall hydrolase/autolysin ec 3.5.1.28 GO0008936 nicotinamidase ec 3.5.1.19 GO0017159 pantetheinase ec 3.5.1.- GO0004593 pantothenase ec 3.5.1.22 GO0008953 penicillin amidase ec 3.5.1.11 GO0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase peptide:N-glycanase PNGase Enzyme that catalyzes hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. ec 3.5.1.52 GO0009014 succinyl-diaminopimelate desuccinylase ec 3.5.1.18 GO0009017 succinylglutamate desuccinylase ec 3.5.1.- GO0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase ec 3.5.1.- GO0009039 urease ec 3.5.1.5 interpro IPR002026 Urease gamma subunit interpro IPR002019 Urease beta subunit interpro IPR001924 Urease alpha subunit GO0016813 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines ec 3.5.3.- GO0008783 agmatinase ec 3.5.3.11 GO0004037 allantoicase ec 3.5.3.4 GO0004053 arginase ec 3.5.3.1 GO0016990 arginine deiminase ec 3.5.3.6 interpro IPR003876 Arginine deiminase GO0016980 creatinase ec 3.5.3.3 interpro IPR000587 Creatinase GO0016403 dimethylargininase ec 3.5.3.18 GO0004668 protein-arginine deiminase ec 3.5.3.15 GO0009015 succinylarginine dihydrolase ec 3.5.3.- GO0004848 ureidoglycolate hydrolase ec 3.5.3.19 GO0016815 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in nitriles ec 3.5.5.- GO0000257 nitrilase An enzyme that acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides (from the EC). sgd kd ec 3.5.5.1 GO0016816 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in other compounds ec 3.5.99.- GO0016788 hydrolase, acting on ester bonds interpro IPR002224 5'-Nucleotidase interpro IPR001559 Phosphotriesterase family GO0016789 carboxylic ester hydrolase interpro IPR002018 Carboxylesterases type-B ec 3.1.1.- GO0003847 2-acetyl-1-alkylglycerophosphocholine esterase ec 3.1.1.47 interpro IPR003155 Platelet activating factor acetylhydrolase GO0017057 6-phosphogluconolactonase ec 3.1.1.31 GO0008126 acetylesterase ec 3.1.1.6 GO0004045 aminoacyl-tRNA hydrolase enzyme catalyzing the hydrolysis of the peptidyl-tRNA released from the ribosomal P-site upon termination of translation. Considered part of the large ribosomal subunit. ec 3.1.1.29 mgd hjd interpro IPR001328 Peptidyl-tRNA hydrolase GO0004064 arylesterase interpro IPR002640 Arylesterase ec 3.1.1.2 GO0004091 carboxylesterase esterase, unknown substrate GO0004302 ec 3.1.1.1 ec 3.1.1.- GO0003990 acetylcholinesterase ec 3.1.1.7 interpro IPR001445 Insect acetylcholinesterase interpro IPR000908 Fish acetylcholinesterase GO0004453 juvenile-hormone esterase A carboxylesterase that hydrolyses the ester linkage of juvenile hormone. embl AF304352 ec 3.1.1.59 GO0008806 carboxymethylenebutenolidase ec 3.1.1.45 GO0004104 cholinesterase ec 3.1.1.8 GO0004341 gluconolactonase ec 3.1.1.17 GO0016298 lipase interpro IPR002918 Lipase (class 2) ec 3.1.1.- GO0004465 lipoprotein lipase interpro IPR002330 Lipoprotein lipase ec 3.1.1.34 GO0004620 phospholipase interpro IPR003187 Phospholipase A1 interpro IPR002642 Lysophospholipase catalytic domain ec 3.1.1.- GO0004622 lysophospholipase ec 3.1.1.5 GO0008970 phospholipase A1 ec 3.1.1.32 interpro IPR002334 Dol/Ves 1 allergen GO0017063 phosphatidylserine-specific phospholipase A1 ec 3.1.1.32 GO0004623 phospholipase A2 interpro IPR001211 Phospholipase A2 ec 3.1.1.4 GO0004626 cytosolic phospholipase A2 ec 3.1.1.4 GO0004627 calcium-dependent cytosolic phospholipase A2 ec 3.1.1.4 GO0004628 calcium-independent cytosolic phospholipase A2 ec 3.1.1.4 GO0004624 secreted phospholipase A2 ec 3.1.1.4 GO0004625 calcium-dependent secreted phospholipase A2 ec 3.1.1.4 GO0004806 triacylglycerol lipase interpro IPR002331 Pancreatic lipase interpro IPR002333 Hepatic lipase interpro IPR002921 Lipase (Class 3) ec 3.1.1.3 GO0000225 N-acetylglucosaminylphosphatidylinositol deacetylase The second step enzyme catalyzing the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. Catalyzes the de-N-acetylation of GlcNAc-PI to GlcN-PI. ec 3.1.1.69 GO0008984 protein-glutamate methylesterase ec 3.1.1.61 GO0004771 sterol esterase ec 3.1.1.13 GO0016794 diphosphoric monoester hydrolase ec 3.1.7.- GO0008893 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase ec 3.1.7.2 GO0004518 nuclease Any enzyme that catalyzes the hydrolysis of ester linkages within nucleic acids. interpro IPR000080 Staphylococcus nuclease (SNase) homologues interpro IPR000513 5'3'-Exonuclease N- and I-domains isbn 0198547684 sp_kw Nuclease interpro IPR002071 Thermonuclease family interpro IPR001943 UvrB/uvrC motif interpro IPR000305 UvrC homology region 1 interpro IPR001532 Xeroderma pigmentosum group G/yeast RAD superfamily ec 3.1.-.- interpro IPR001162 Excinuclease ABC subunit C domain 2 GO0004536 deoxyribonuclease An enzyme that catalyzes the hydrolysis of ester linkages within deoxyribonucleic acid. sgd mah interpro IPR001582 Deoxyribonuclease I GO0004537 caspase-activated deoxyribonuclease GO0004520 endodeoxyribonuclease An enzyme that catalyzes the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. sgd mah interpro IPR002176 Crossover junction endodeoxyribonuclease RuvC GO0004519 endonuclease Any enzyme that catalyzes the hydrolysis of ester linkages within nucleic acids by creating internal breaks. interpro IPR001982 LAGLIDADG and HNH domains of site-specific DNA intron endonuclease interpro IPR001719 AP endonucleases family 2 interpro IPR000097 AP endonucleases family 1 interpro IPR003058 Cloacin interpro IPR001604 DNA/RNA non-specific endonuclease sp_kw Endonuclease sgd mah interpro IPR003611 Intron-encoded nuclease repeat 2 interpro IPR003154 S1/P1 Nuclease ec 3.1.-.- interpro IPR001044 Xeroderma pigmentosum DNA complementing protein, Group G (XPGC) interpro IPR001502 Endonuclease III interpro IPR003651 Iron-sulphur binding domain interpro IPR002711 HNH endonuclease GO0016888 endodeoxyribonuclease, producing 5'-phosphomonoesters ec 3.1.21.- GO0004530 deoxyribonuclease I Enzyme that catalyzes endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. ec 3.1.21.1 GO0008833 deoxyribonuclease IV (phage T4-induced) ec 3.1.21.2 GO0009035 type I site-specific deoxyribonuclease ec 3.1.21.3 GO0015666 restriction endodeoxyribonuclease GO0009036 type II site-specific deoxyribonuclease ec 3.1.21.4 GO0015668 type III site-specific deoxyribonuclease ec 3.1.21.5 GO0016889 endodeoxyribonuclease, producing other than 5'-phosphomonoesters ec 3.1.22.- GO0008821 crossover junction endoribonuclease ec 3.1.22.4 GO0004531 deoxyribonuclease II Enzyme that catalyzes endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products. ec 3.1.22.1 GO0008844 endodeoxyribonuclease RUS Holliday junction resolvase ec 3.1.22.- GO0009381 excinuclease ABC GO0017108 flap endonuclease Endonuclease cleaving a 5' flap structure in DNA, but not other DNA structures. prot P39749 GO0000014 single-stranded DNA specific endodeoxyribonuclease GO0016890 site-specific endodeoxyribonuclease, specific for altered base ec 3.1.25.- GO0004529 exodeoxyribonuclease Deoxyribonuclease that catalyzes sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. sgd mah GO0004527 exonuclease Any enzyme that catalyzes the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. sgd mah interpro IPR001616 Alphaherpesvirus alkaline exonuclease interpro IPR000520 Exonuclease interpro IPR003701 DNA repair exonuclease sp_kw Exonuclease interpro IPR003021 Repair protein Rad1/Rec1 interpro IPR003011 Rad1 repair protein GO0016895 exodeoxyribonuclease, producing 5'-phosphomonoesters ec 3.1.11.- GO0008296 3'-5' exodeoxyribonuclease Deoxyribonuclease that catalyzes sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. sgd mah interpro IPR003027 Rec1 exonuclease GO0008408 3'-5' exonuclease interpro IPR002562 3'-5' exonuclease interpro IPR001001 DNA polymerase III, beta chain interpro IPR002064 DNA-directed DNA polymerase family B GO0008311 double-stranded DNA specific 3'-5' exodeoxyribonuclease Deoxyribonuclease that catalyzes sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. sgd mah GO0008309 double-stranded DNA specific exodeoxyribonuclease Deoxyribonuclease that catalyzes sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. sgd mah GO0008310 single-stranded DNA specific 3'-5' exodeoxyribonuclease Deoxyribonuclease that catalyzes sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule. sgd mah GO0008297 single-stranded DNA specific exodeoxyribonuclease Deoxyribonuclease that catalyzes sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. sgd mah GO0008852 exodeoxyribonuclease I ec 3.1.11.1 GO0008853 exodeoxyribonuclease III ec 3.1.11.2 GO0008854 exodeoxyribonuclease V ec 3.1.11.5 GO0008855 exodeoxyribonuclease VII interpro IPR003753 Exonuclease VII, large subunit interpro IPR003761 Exonuclease VII, small subunit ec 3.1.11.6 GO0008856 exodeoxyribonuclease X ec 3.1.11.- GO0008858 exonuclease VIII ec 3.1.11.- GO0008946 oligoribonuclease ec 3.1.11.- GO0004540 ribonuclease Any of a group of nuclease enzymes that cleave phosphodiester bonds in chains of RNA. sgd mah interpro IPR001900 Ribonuclease II domain GO0008997 ribonuclease R ec 3.1.11.- GO0008845 endonuclease VIII GO0004521 endoribonuclease An enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. ec 3.1.26.- sgd mah interpro IPR003212 7kD DNA-binding protein interpro IPR001568 Ribonuclease T2 family interpro IPR001887 Barnase interpro IPR000026 Guanine-specific ribonuclease N1 and T1 GO0016894 endoribonuclease, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters ec 3.1.31.- GO0016893 endoribonuclease, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters ec 3.1.30.- GO0016891 endoribonuclease, producing 5'-phosphomonoesters ec 3.1.26.- GO0004523 ribonuclease H Enzyme that catalyzes the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. interpro IPR001352 Ribonuclease HII interpro IPR002156 RNase H interpro IPR001462 Hepadnaviral P protein C-terminal domain ec 3.1.26.4 GO0004524 ribonuclease H1 ec 3.1.26.4 GO0004525 ribonuclease III Enzyme that catalyzes the endonucleolytic cleavage of RNA to 5'-phosphomonoesters; cleaves multimeric tRNA precursor at the spacer region; also involved in processing of precursor rRNA, hnRNA and early T7-mRNA; also cleaves double-stranded DNA. interpro IPR000999 Ribonuclease III family ec 3.1.26.3 GO0016443 bidentate ribonuclease III A ribonuclease III that digests double-stranded RNAs into 22-nucleotide products that then associate to the RNA-induced silencing complex and serve as guide RNAs for post-translational RNA interference. ec 3.1.26.- pmid 11201747 GO0004526 ribonuclease P Enzyme that catalyzes the endonucleolytic cleavage of RNA, removing 5'- extra nucleotides from tRNA precursor. ec 3.1.26.5 interpro IPR000100 Bacterial ribonuclease P protein GO0004549 tRNA-specific ribonuclease interpro IPR002381 Ribonuclease PH GO0008419 RNA lariat debranching enzyme GO0016892 endoribonuclease, producing other than 5'-phosphomonoesters ec 3.1.27.- GO0008847 enterobacter ribonuclease ec 3.1.27.6 GO0004522 pancreatic ribonuclease ribonuclease A ribonuclease I Enzyme that catalyzes the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. interpro IPR001427 Pancreatic ribonuclease family ec 3.1.27.5 GO0000213 tRNA-intron endonuclease tRNA-splicing endonuclease Enzyme that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. interpro IPR002827 tRNA intron endonuclease ec 3.1.27.9 GO0016541 intein Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity. go mah GO0000175 3'-5' exoribonuclease Ribonuclease that catalyzes sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. sgd mah ec 3.1.13.- interpro IPR001247 3' exoribonuclease family GO0016896 exoribonuclease, producing 5'-phosphomonoesters ec 3.1.13.- GO0008859 exoribonuclease II Exoribonuclease that cleaves RNA in the 3'- to 5'- direction to yield 5'-phosphomononucleotides. isbn 0198547684 ec 3.1.13.1 GO0008409 5'-3' exonuclease interpro IPR002421 5'-3' Exonuclease GO0004534 5'-3' exoribonuclease Ribonuclease that catalyzes sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. sgd mah ec 3.1.13.- GO0008857 exonuclease IX GO0016797 exonuclease, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters ec 3.1.16.- GO0016796 exonuclease, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters ec 3.1.15.- GO0004532 exoribonuclease Ribonuclease that catalyzes sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. sgd mah GO0016897 exoribonuclease, producing 3'-phosphomonoesters ec 3.1.14.- GO0004533 exoribonuclease H Enzyme that catalyzes exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5'- to 3'- and 3'- to 5'-directions. ec 3.1.13.2 GO0004535 poly(A)-specific ribonuclease Enzyme that catalyzes the exonucleolytic cleavage of poly(A) to 5'-AMP. isbn 0198547684 ec 3.1.13.4 GO0004528 phosphodiesterase I ec 3.1.4.1 GO0008081 phosphodiesterase ec 3.1.4.- GO0008995 ribonuclease E GO0008996 ribonuclease G GO0000171 ribonuclease MRP Abbr. RNase MRP; a ribonucleoprotein complex that performs the first cleavage in rRNA transcript processing and is also involved in mitochondrial RNA processing. pmid 10690410 GO0016792 phosphoric diester hydrolase ec 3.1.4.- GO0004112 cyclic-nucleotide phosphodiesterase ec 3.1.4.- GO0004113 2',3'-cyclic nucleotide 3'-phosphodiesterase ec 3.1.4.37 GO0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase ec 3.1.4.16 GO0004114 3',5'-cyclic-nucleotide phosphodiesterase ec 3.1.4.17 interpro IPR002073 3'5'-cyclic nucleotide phosphodiesterase GO0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase ec 3.1.4.- GO0004115 cAMP-specific phosphodiesterase ec 3.1.4.- interpro IPR000396 cAMP phosphodiesterases class-II GO0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase ec 3.1.4.- GO0004116 cGMP-specific phosphodiesterase ec 3.1.4.- GO0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase ec 3.1.4.- GO0004120 photoreceptor cyclic-nucleotide phosphodiesterase ec 3.1.4.- GO0008889 glycerophosphodiester phosphodiesterase ec 3.1.4.46 GO0004434 inositol/phosphatidylinositol phosphodiesterase ec 3.1.4.- GO0004436 1-phosphatidylinositol phosphodiesterase ec 3.1.4.10 GO0004435 1-phosphatidylinositol-4,5-biphosphate phosphodiesterase ec 3.1.4.11 GO0004767 sphingomyelin phosphodiesterase ec 3.1.4.12 GO0017005 tyrosyl-DNA phosophodiesterase The hydrolysis of covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I (0003917) and DNA. pmid 10521354 GO0008770 [acyl-carrier protein] phosphodiesterase ec 3.1.4.14 GO0004629 phospholipase C interpro IPR001192 Phosphoinositide-specific phospholipase C (PLC) interpro IPR001531 Prokaryotic zinc-dependent phospholipase C interpro IPR003633 Variant-surface-glycoprotein phospholipase C ec 3.1.4.3 interpro IPR001711 Phosphatidylinositol-specific phospholipase C, Y domain interpro IPR000909 Phosphatidylinositol-specific phospholipase C, X domain GO0004630 phospholipase D choline phosphatase ec 3.1.4.4 GO0004621 glycoprotein phospholipase D ec 3.1.4.50 interpro IPR001028 Phospholipase D, glycoprotein specific GO0016791 phosphoric monoester hydrolase ec 3.1.3.- GO0003850 2-deoxyglucose-6-phosphatase ec 3.1.3.68 GO0016158 3-phytase ec 3.1.3.8 GO0003869 4-nitrophenylphosphatase ec 3.1.3.41 GO0008707 6-phytase ec 3.1.3.26 GO0003993 acid phosphatase interpro IPR001011 Bacterial acid phosphatase, class A ec 3.1.3.2 interpro IPR000560 Histidine acid phosphatase interpro IPR003266 Purple acid phosphatase GO0004035 alkaline phosphatase ec 3.1.3.1 GO0004063 aryldialkylphosphatase ec 3.1.8.1 GO0004083 bisphosphoglycerate phosphatase ec 3.1.3.13 GO0004330 fructose-2,6-bisphosphate 2-phosphatase ec 3.1.3.46 GO0004331 fructose-bisphosphatase ec 3.1.3.11 GO0008877 glucose-1-phosphatase ec 3.1.3.10 GO0004346 glucose-6-phosphatase ec 3.1.3.9 GO0000121 glycerol-1-phosphatase Enzyme that catalyzes the hydrolysis of glycerol 1-phosphate to yield glycerol and orthophosphate. ec 3.1.3.21 GO0004401 histidinol-phosphatase ec 3.1.3.15 GO0004437 inositol/phosphatidylinositol phosphatase The removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. interpro IPR000300 Inositol polyphosphate related phosphatase family fb hb interpro IPR000760 Inositol monophosphatase GO0016312 inositol bisphosphate phosphatase The removal of one of the two phosphate groups of an inositol bisphosphate. fb hb GO0016315 inositol-1,3,-bisphosphate 3-phosphatase The removal of a phosphate group from the carbon-3 position of D-myo-inositol 1,3-bisphosphate. ec 3.1.3.65 GO0004441 inositol-1,4,-bisphosphate 1-phosphatase The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4-bisphosphate. Can also be the removal of the phosphate group from the carbon-1 position of inositol 1,3,4-triphosphate to produce inositol 3,4-bisphosphate. ec 3.1.3.57 GO0016316 inositol-3,4,-bisphosphate 4-phosphatase The removal of a phosphate group from the carbon-4 position of D-myo-inositol 3,4-bisphosphate. ec 3.1.3.66 GO0004446 inositol-1,3,4,5-tetrakiphosphate 3-phosphatase The removal of a phosphate group from the carbon-3 position of D-myo-inositol 1,3,4,5-tetrakisphosphate. ec 3.1.3.62 GO0017161 inositol-1,3,4-triphosphate 4-phosphatase ec 3.1.3.- GO0016313 inositol-1,4,5-triphosphate phosphatase The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate. fb hb GO0004444 inositol-1,4,5-triphosphate 1-phosphatase The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate. ec 3.1.3.61 GO0004445 inositol-1,4,5-triphosphate 5-phosphatase The removal of a phosphate group from the carbon-5 position of D-myo-inositol 1,4,5-trisphosphate. Can also be the removal of the carbon-5 position phosphate group of 1,3,4,5-tetrakisphosphate. ec 3.1.3.56 GO0008934 myo-inositol-1(or 4)-monophosphatase The removal of a phosphate group from myo-inositol 1-monophosphate or from myo-inositol 4-phosphate. ec 3.1.3.25 GO0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase The removal of a phosphate group from the carbon-3 position of phosphatidyl inositol-3,4,5-trisphosphate. ec 3.1.3.67 GO0004438 phosphatidylinositol-3-phosphatase The removal of a phosphate group from phosphatidylinositol 3-phosphate to produce phosphatidylinositol. ec 3.1.3.64 GO0004439 phosphatidylinositol-bisphosphatase The removal of a phosphate group from phosphatidyl-myo-inositol 4,5-bisphosphate to produce phosphatidylinositol 4-phosphate. ec 3.1.3.36 GO0008252 nucleotidase ec 3.1.3.- GO0008441 3'(2'),5'-bisphosphate nucleotidase ec 3.1.3.7 GO0008254 3'-nucleotidase ec 3.1.3.6 GO0008253 5'-nucleotidase ec 3.1.3.5 GO0008195 phosphatidate phosphatase GO0004606 phosphatidate phosphohydrolase ec 3.1.3.4 GO0008962 phosphatidylglycerophosphatase ec 3.1.3.27 GO0008967 phosphoglycolate phosphatase ec 3.1.3.18 GO0008969 phosphohistidine phosphatase ec 3.1.3.- GO0004647 phosphoserine phosphatase ec 3.1.3.3 GO0004651 polynucleotide 5'-phosphatase ec 3.1.3.33 GO0017120 polyphosphoinositide phosphatase The conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization. pmid 10224048 GO0004721 protein phosphatase Any enzyme that hydrolyzes phosphate groups from proteins. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. isbn 0198547684 interpro IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase family ec 3.1.3.- GO0008965 phosphoenolpyruvate--protein phosphatase ec 2.7.3.9 GO0016780 phosphotransferase, for other substituted phosphate groups ec 2.7.8.- GO0004722 protein serine/threonine phosphatase interpro IPR000222 Protein phosphatase 2C subfamily ec 3.1.3.16 interpro IPR000934 Serine/threonine specific protein phosphatase GO0004723 calcium-dependent protein serine/threonine phosphatase calcineurin GO0005509 calcium binding interpro IPR001299 Ependymin interpro IPR001881 Calcium-binding EGF-like domain interpro IPR002126 Cadherin domain interpro IPR003299 Flagellar calcium-binding protein (calflagin) interpro IPR001580 Calreticulin family sp_kw Calcium-binding sp_kw Annexin interpro IPR003915 Polycystic kidney disease type 2 protein interpro IPR001464 Annexin family interpro IPR000545 Lactalbumin interpro IPR000853 Nematode metallothionein interpro IPR002048 EF-hand family interpro IPR003355 RTX N-terminal domain interpro IPR002392 Annexin type V interpro IPR003367 Thrombospondin type 3 repeat interpro IPR001211 Phospholipase A2 interpro IPR001343 Hemolysin-type calcium-binding region interpro IPR002390 Annexin type III interpro IPR002388 Annexin type I interpro IPR001393 Calsequestrin interpro IPR002391 Annexin type IV interpro IPR001382 Glycoside hydrolase family 47 interpro IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain interpro IPR002134 HCP repeats interpro IPR003966 Prothrombin interpro IPR000233 Cadherin cytoplasmic region interpro IPR002389 Annexin type II interpro IPR002393 Annexin type VI interpro IPR001751 S-100/ICaBP type calcium binding protein GO0008596 calcium-dependent protein serine/threonine phosphatase catalyst GO0008597 calcium-dependent protein serine/threonine phosphatase regulator GO0008420 CTD phosphatase ec 3.1.3.16 GO0004724 magnesium-dependent protein serine/threonine phosphatase GO0000163 protein phosphatase type 1 An ATP, Mg2+-dependent protein serine/threonine phosphatase (AMD phosphatase) that consists of a catalytic subunit of 38 kDa and a modulator subunit of 23 kDa, which is subject to phosphorylation, thus activating the phosphatase. sgd mah ec 3.1.3.16 GO0017018 myosin phosphatase ec 3.1.3.16 GO0017019 myosin phosphatase catalyst GO0017021 myosin phosphatase myosin binding GO0017022 myosin binding GO0017020 myosin phosphatase regulator GO0008598 protein phosphatase type 1 catalyst GO0008599 protein phosphatase type 1 regulator GO0000158 protein phosphatase type 2A A protein serine/threonine phosphatase that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine. isbn 0198547684 ec 3.1.3.16 GO0008600 protein phosphatase type 2A catalyst GO0008601 protein phosphatase type 2A regulator interpro IPR002554 Protein phosphatase 2A regulatory B subunit (B56 family) interpro IPR000009 Protein phosphatase 2A regulatory subunit PR55 GO0015071 protein phosphatase type 2C ec 3.1.3.16 GO0009400 receptor signaling protein serine/threonine phosphatase GO0005057 receptor signaling protein interpro IPR003116 Raf-like Ras-binding domain GO0004725 protein tyrosine phosphatase interpro IPR000242 Tyrosine specific protein phosphatase interpro IPR003546 Salmonella/Yersinia modular tyrosine phosphatase ec 3.1.3.48 interpro IPR000106 Low molecular weight phosphotyrosine protein phosphatase interpro IPR003595 Protein tyrosine phosphatase, catalytic domain GO0004726 non-membrane spanning protein tyrosine phosphatase interpro IPR002115 Mammalian LMW phosphotyrosine protein phosphatase GO0004727 prenylated protein tyrosine phosphatase ec 3.1.3.48 GO0004728 receptor signaling protein tyrosine phosphatase tigr_role 22520 201 Signal transduction Phosphatases > GOreceptor signalling protein serine/threonine phosphatase ; GO:0009400 GO0005001 transmembrane receptor protein tyrosine phosphatase GO0008138 protein tyrosine/serine/threonine phosphatase dual-specificity protein phosphatase ec 3.1.3.- interpro IPR000340 Dual specificity protein phosphatase GO0008579 JUN kinase phosphatase ec 3.1.3.- GO0017017 MAP kinase phosphatase ec 3.1.3.- GO0008330 protein tyrosine/threonine phosphatase ec 3.1.3.- GO0004741 pyruvate dehydrogenase (lipoamide) phosphatase ec 3.1.3.43 GO0004805 trehalose phosphatase ec 3.1.3.12 GO0016795 phosphoric triester hydrolase ec 3.1.8.- GO0008484 sulfuric ester hydrolase sulfatase interpro IPR000917 Sulfatase ec 3.1.6.- GO0004065 arylsulfatase ec 3.1.6.1 GO0004098 cerebroside-sulfatase ec 3.1.6.8 GO0015024 glucuronate-2-sulfatase ec 3.1.6.18 GO0004423 iduronate-2-sulfatase ec 3.1.6.13 GO0003943 N-acetylgalactosamine-4-sulfatase arylsulfatase B ec 3.1.6.12 GO0008449 N-acetylglucosamine-6-sulfatase ec 3.1.6.14 GO0004773 steryl-sulfatase ec 3.1.6.2 GO0016790 thiolester hydrolase ec 3.1.2.- GO0016289 CoA hydrolase ec 3.1.2.- interpro IPR002590 Cytosolic long-chain acyl-CoA thioester hydrolase GO0003860 3-hydroxyisobutyryl-CoA hydrolase ec 3.1.2.4 GO0003986 acetyl-CoA hydrolase ec 3.1.2.1 GO0016291 acyl-CoA thioesterase ec 3.1.2.- interpro IPR003703 Acyl-CoA thioesterase GO0016292 acyl-CoA thioesterase I ec 3.1.2.- GO0008778 acyl-CoA thioesterase II ec 3.1.2.- GO0016293 long-chain fatty-acyl-CoA hydrolase ec 3.1.2.2 GO0016290 palmitoyl-CoA hydrolase ec 3.1.2.2 GO0004778 succinyl-CoA hydrolase ec 3.1.2.3 GO0004416 hydroxyacylglutathione hydrolase ec 3.1.2.6 GO0008474 palmitoyl-protein hydrolase interpro IPR002472 Palmitoyl protein thioesterase ec 3.1.2.22 GO0004221 ubiquitin thiolesterase An enzyme that acts on esters formed between thiols and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin. interpro IPR001578 Ubiquitin carboxyl-terminal hydrolases family 1 interpro IPR001394 Ubiquitin carboxyl-terminal hydrolase family 2 ec 3.1.2.15 GO0016297 [acyl-carrier protein] hydrolase ec 3.1.2.14 GO0004312 fatty-acid synthase interpro IPR003965 Fatty acid synthase ec 2.3.1.85 GO0016294 lauroyl-[acyl-carrier protein] hydrolase ec 3.1.2.14 GO0016295 myristoyl-[acyl-carrier protein] hydrolase ec 3.1.2.14 GO0004320 oleoyl-[acyl-carrier protein] hydrolase ec 3.1.2.14 GO0016296 palmitoyl-[acyl-carrier protein] hydrolase ec 3.1.2.14 GO0016793 triphosphoric monoester hydrolase ec 3.1.5.- GO0008832 deoxyguanosinetriphosphate triphosphohydrolase ec 3.1.5.1 GO0016801 hydrolase, acting on ether bonds ec 3.3.-.- GO0016803 ether hydrolase ec 3.3.2.- GO0004463 leukotriene-A4 hydrolase ec 3.3.2.6 GO0004301 epoxide hydrolase ec 3.3.2.3 GO0008096 juvenile hormone epoxide hydrolase ec 3.3.2.- GO0008908 isochorismatase ec 3.3.2.1 interpro IPR003881 Isochorismatase GO0016802 thioether hydrolase ec 3.3.1.- GO0004013 adenosylhomocysteinase ec 3.3.1.1 interpro IPR000043 S-adenosyl-L-homocysteine hydrolase GO0016798 hydrolase, acting on glycosyl bonds ec 3.2.-.- GO0016799 hydrolase, hydrolyzing N-glycosyl compounds ec 3.2.2.- GO0008782 adenosylhomocysteine nucleosidase ec 3.2.2.9 GO0003875 ADP-ribosylarginine hydrolase ec 3.2.2.19 GO0008714 AMP nucleosidase ec 3.2.2.4 GO0008534 8-oxoguanine DNA glycosylase ec 3.2.2.- GO0003905 DNA-3-methyladenine glycosidase II interpro IPR003180 Methylpurine-DNA glycosylase (MPG) ec 3.2.2.21 GO0008725 DNA-3-methyladenine glycosylase I ec 3.2.2.20 GO0008930 methylthioadenosine nucleosidase ec 3.2.2.16 GO0003953 NAD(+) nucleosidase interpro IPR003193 ADP-ribosyl cyclase (CB38/157) ec 3.2.2.5 GO0008477 purine nucleosidase ec 3.2.2.1 GO0016997 alpha-sialidase GO0016996 endo-alpha-sialidase ec 3.2.1.129 GO0004308 exo-alpha-sialidase neuraminidase ec 3.2.1.18 interpro IPR001860 Glycoside hydrolase family 34 GO0016160 amylase ec 3.2.1.- GO0004556 alpha-amylase ec 3.2.1.1 interpro IPR000461 Glycoside hydrolase family 13 GO0016161 beta-amylase interpro IPR001554 Glycoside hydrolase family 14 ec 3.2.1.2 interpro IPR001371 Plant beta-amylase GO0004564 beta-fructofuranosidase invertase ec 3.2.1.26 GO0004566 beta-glucuronidase ec 3.2.1.31 GO0008810 cellulase endo-1,4-beta glucanase endoglucanase interpro IPR002594 Glycoside hydrolase family 12 ec 3.2.1.4 interpro IPR000334 Glycoside hydrolase family 45 GO0016162 cellulose 1,4-beta-cellobiosidase exoglucanase ec 3.2.1.91 GO0004568 chitinase interpro IPR000726 Glycoside hydrolase family 19 ec 3.2.1.14 GO0008843 endochitinase ec 3.2.1.14 GO0016977 chitosanase interpro IPR000400 Glycoside hydrolase family 46 ec 3.2.1.132 GO0015928 fucosidase ec 3.2.1.- GO0004560 alpha-L-fucosidase interpro IPR000933 Glycosyl hydrolase family 29 (Alpha-L-fucosidase) ec 3.2.1.51 GO0015925 galactosidase ec 3.2.1.- GO0004557 alpha-galactosidase interpro IPR002252 Glycoside hydrolase family 36 interpro IPR002287 Melibiase ec 3.2.1.22 GO0004565 beta-galactosidase ec 3.2.1.23 interpro IPR001944 Glycoside hydrolase family 35 interpro IPR003476 Beta-galactosidase GO0004558 alpha-glucosidase GO0016982 maltase ec 3.2.1.20 GO0004562 alpha-glucosidase II ec 3.1.2.20 ec 3.2.1.20 GO0008422 beta-glucosidase ec 3.2.1.21 GO0008706 6-phospho-beta-glucosidase ec 3.2.1.86 GO0016983 cytokine beta-glucosidase GO0004338 glucan 1,3-beta-glucosidase ec 3.2.1.58 GO0004339 glucan 1,4-alpha-glucosidase ec 3.2.1.3 interpro IPR000165 Glycoside hydrolase family 15 GO0004573 mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) ec 3.2.1.106 GO0004574 oligo-1,6-glucosidase sucrose-isomaltase ec 3.2.1.10 GO0004575 sucrose-alpha-glucosidase ec 3.2.1.48 GO0015929 hexosaminidase ec 3.2.1.- GO0008456 alpha-N-acetylgalactosaminidase ec 3.2.1.49 GO0004561 alpha-N-acetylglucosaminidase ec 3.2.1.50 GO0016231 beta-N-acetylglucosaminidase GO0004563 beta-N-acetylhexosaminidase interpro IPR001540 Glycoside hydrolase family 20 ec 3.2.1.52 GO0004415 hyaluronoglucosaminidase interpro IPR001439 Sperm surface protein PH20 (hyaluronidase) interpro IPR001968 Glycoside hydrolase family 56 ec 3.2.1.35 interpro IPR001329 Allergen Api/Dol m 2 GO0003944 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase ec 3.1.4.45 GO0003940 L-iduronidase ec 3.2.1.76 GO0000016 lactase ec 3.2.1.108 GO0015923 mannosidase ec 3.2.1.- GO0004559 alpha-mannosidase ec 3.2.1.24 interpro IPR000602 Glycoside hydrolase family 38 GO0008496 endo-alpha-D-mannosidase Glycoprotein N-linked oligosaccharide processing enzyme; endo-alpha-mannosidase; Golgi apparatus-located enzyme; involved in early processing of N-linked oligosaccharides of glycoproteins; provides alternate processing pathway evident during glucosidase blockade by inhibitors or genetic defect. embl AF023657 GO0004567 beta-mannosidase ec 3.2.1.25 GO0016985 mannan endo-1,4-beta-mannosidase ec 3.2.1.78 GO0008727 GDP-mannose mannosyl hydrolase